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Immunoprecipitation-based assay for predicting in vivo efficacy of beta-amyloid antibodies
Immunoprecipitation-based assay for predicting in vivo efficacy of beta-amyloid antibodies
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机译:基于免疫沉淀的测定法可预测β-淀粉样蛋白抗体的体内功效
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摘要
In various aspects, the present invention provides methods and kits for predicting the therapeutic efficacy of an immunological reagent, identifying an immunological reagent having therapeutic efficacy, or both, for the treatment of an amyloidogenic disorder by comparing the amount of Aβ monomer in an Aβ preparation which binds to the immunological reagent to an amount of one or more Aβ oligomers in the Aβ preparation which bind to the immunological reagent to determine a relative bound amount, and predicting the efficacy of the immunological reagent, identifying an immunological reagent having therapeutic efficacy, or both, for the treatment of an amyloidogenic disorder based at least on the relative bound amount.
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