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RNA interference mediated inhibition of desmoglein gene expression using short interfering nucleic acid (siNA)
RNA interference mediated inhibition of desmoglein gene expression using short interfering nucleic acid (siNA)
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机译:RNA干扰介导的使用短干扰核酸(siNA)抑制桥粒芯蛋白基因表达
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摘要
This invention relates to compounds, compositions, and methods useful for modulating Desmoglein (e.g, DSG1, DSG2, DSG3, and/or DSG4) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of Desmoglein gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (mRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of Desmoglein genes.
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