Peptides, DNAs, RNAs, and compounds for inhibiting or inducing adrenomedullin activity, and use of the same

摘要

Pharmaceutical compositions containing adrenomedullin antagonist peptides, DNA, RNA compounds inhibitory on adrenomedullin activity, resulting in the efficient blockade of the induction of macroangiogenesis or vasculogenesis of more than 8 μm (in case of murine models), suppress the proliferation of cancer cells due to that inhibitory effect and suppress the protective activity of adrenomedullin. Accordingly, the pharmaceutical compositions of the present invention described herein can be used to treat various cancers, including, but not limited to, stomach cancer, colorectal cancer, lung cancer, ovarian cancer, liver cancer, and pancreatic cancer. Pharmaceutical compositions containing adrenomedullin expression vectors described herein induce macroangiogenesis and, accordingly are effective in treating cardiovascular and renal diseases such as congestive heart failure, myocardial infarction, hypertension, chronic renal failure, stroke, diabetes mellitus, and septic shock.