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Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
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机译:与端粒长度和/或端粒酶活性有关的疾病的治疗和诊断
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摘要
Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
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