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Interstitial collagenase molecular motor
Interstitial collagenase molecular motor
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机译:间质胶原酶分子运动
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摘要
A novel interstitial collagenase is disclosed which acts as an ATP-independent molecular motor driven by the proteolysis of substrate collagen. Also disclosed is a method of reacting interstitial collagenase with a collagen fibril to encounter multiple cleavage sites without substantial dissociation of said interstitial collagenase and thereby act as a molecular motor driven by the proteolysis of substrate collagen. The invention thus is useful as a research tool in the tissue remodeling and cell-matrix interaction. The invention also has significant utility in the screening and development of inhibitors of interstitial collagenase and as a research tool for evaluating the activity and effect of drug candidates.
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