首页>
外国专利>
Novel high-throughput screening method of drug for bioactive protein
Novel high-throughput screening method of drug for bioactive protein
展开▼
机译:一种新的生物活性蛋白药物高通量筛选方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention is intended to provide a safe and quick means for screening a drug to a bioactive protein, in particular, an inhibitor, using a cell-free protein synthesis system with the use of a wheat embryo extract solution. The present inventors have strenuously studied to solve the matters above and finally completed the present invention by, in a system with the use of a wheat embryo, among cell-free protein synthesis means, constructing a synthesis system of a bioactive protein while sustaining its activities, and constructing a system for screening an inhibitor candidate to SARS 3CLpro, as an example using the synthesis system.
展开▼
机译:本发明旨在提供一种安全快速的方法,该方法使用无细胞蛋白质合成系统和小麦胚芽提取物溶液来筛选针对生物活性蛋白质(尤其是抑制剂)的药物。本发明人为解决上述问题而进行了艰苦的研究,最终通过在使用小麦胚的系统中在无细胞蛋白质合成手段中构建生物活性蛋白质的合成系统并维持其活性,从而完成了本发明。 ,并以合成系统为例,构建了筛选SARS 3CL pro Sup>的候选抑制剂的系统。
展开▼