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Recombinant cage-like protein, method for producing the same, precious metal-recombinant cage-like protein complex, method for producing the same and recombinant DNA
Recombinant cage-like protein, method for producing the same, precious metal-recombinant cage-like protein complex, method for producing the same and recombinant DNA
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机译:重组笼状蛋白,其制备方法,贵金属重组笼状蛋白复合物,制备方法和重组DNA
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摘要
The present invention relates to a precious metal-recombinant apoferritin complex produced by recombination technique, wherein the precious metal is gold (Au) or platinum (Pt), and wherein the residues of glutamic acid and aspartic acid in a channel of apoferritin complex are substituted with small polar amino acid residues or/and noncharged amino acid residues, e.g., serine, or/and with basic amino acid residues, e.g., lysine. The substitution prevents a repulsive force due to electrostatic interaction between a metal ion, e.g., (AuCl4)− that has a negative charge and a negative amino acid residue of the apoferritin, and facilitates the capture of (AuCl4)− into holding portion in the channel of said metal-recombinant apoferritin complex. The captured (AuCl4)− is subsequently reduced to Au, and thus the gold-recombinant apoferritin complex is produced.
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