Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents

摘要

Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of polyphenol catechins that occur in green tea, such as epigallocatichin-3-gallate (EGCG), and have the structure of formula (I); wherein R¹ through R¹¹ are defined herein. Preferred R⁴ moieties are selected from O, S, NH and CH₂, and in exemplary compounds, R⁴ is O and R⁵ is a tri-substituted aroyloxy substituent, such as a 3,4,5-substituted benzoyloxy group. Pharmaceutical compositions are provided as well, as are methods of chemotherapy and chemoprevention.