Non-human animal models of atherosclerosis and methods of use thereof

摘要

The present invention provides transgenic, non-human animals comprising a transgene that encodes apolipoprotein(a), which animal exhibits an atherosclerotic phenotype. The present invention further provides transgenic, non-human animals comprising a transgene that encodes apolipoprotein(a) and a transgene that encodes apolipoprotein B-100, which animal exhibits an atherosclerotic phenotype. The present invention further provides methods of identifying agents that reduce atherosclerosis, as well as agents identified by the methods.