Pyridinyl substituted (1,2,3,)triazoles as inhibitors of the tgf-beta signalling pathway

摘要

The invention relates to novel triazole derivatives which are inhibitors of the transforming growth factor, (“TGF”)-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.