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Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution
Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution
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机译:水溶液中未保护或N端半胱氨酸保护的肽的固相天然化学连接
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摘要
The present invention provides methods, apparatus and kits for synthesizing assembled peptides and proteins on a solid phase with sequential ligation of three or more unprotected peptide segments using chemoselective and mild ligation chemistries in aqueous solution. Also provided are methods of monitoring solid phase sequential ligation reactions using MALDI or electrospray ionization mass spectrometry of reaction products.
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