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Modulation of hedgehog-mediated signaling pathway
Modulation of hedgehog-mediated signaling pathway
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机译:刺猬介导的信号通路的调节
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摘要
The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
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