Induction of heterozygous FV Leiden carrier status to reduce mortality in sepsis and to prevent organ damage caused by inflammation and/or ischemia-reperfusion injury

摘要

A method of treating a disease is disclosed. In one embodiment, the method comprises administering to a patient an effective amount of factor V protein or fragment of factor V protein, wherein the amount of protein is sufficient to alleviate or prevent disease symptoms and wherein the protein is resistant to inactivation by APC.