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Peptide conjugates for the stabilization of membrane proteins and interactions with biological membranes
Peptide conjugates for the stabilization of membrane proteins and interactions with biological membranes
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机译:肽共轭物,用于稳定膜蛋白并与生物膜相互作用
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摘要
The present invention provides a novel class of detergents referred to herein as lipopeptide detergents. Lipopeptide detergents comprise an amphipathic α-helical peptide having a hydrophobic or neutral face and a hydrophilic face. To each end of this peptide is covalently linked an aliphatic hydrocarbon tail, these aliphatic tails being linked thereto such that they associate with the hydrophobic or neutral face of the peptide. Lipopeptide detergents can advantageously be used to stabilize membrane proteins in the absence of a phospholipid bilayer in a manner that preserves the native conformation and permits the subsequent crystallization thereof.
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