Derivatives of 1-benzyl-5 - piperazin-1-yl - 3,4 Dihydro 1h quinazolin - 2 - One derivatives and their 1h benzo (1,2,6) thiadiazine - 2.2 - dioxides and 1,4 - dihydro - benzo (d) (1.3) - 2 - ona oxazines as 5-ht receptor modulators. For the treatment of Diseases of the central nervous system.

摘要

Acquisition methods, drug synthesis and use containing them. Item 1: a formula compound (1)Or a pharmaceutically acceptable salt, where y is C or s, M is C, M is m, y is C, y is m, y is s, n is 1 or 2, P is 0 to 3, q is 1 to 3, Z is r-o-so2,R is a number of 0-2, each RA and Rb is independent of each other, which is hydrogen or tar; X is ch or N; each R1, regardless of its appearance: halogenated; tar; halogenated tar; different tar; alcox; cyanogen; - S (o) s-rc; - C (= O) - ncrd; - s o 2-ncrd; - n (RC) - C (= O) - Rd; O-C (= O) RC; S is a quantity of 0-2, while RC and RD are independent, which are hydrogen or tar; R2 is an alternative arilo or alternative arilo; R2 is a preference for arilo, which is more inclined to optional phenyl, which is replaced by one or more trifluoro-1, halogenated-2, cyanogen, C1-6 tar or alcox C1-6; a This is - nr3-u-o, where R3 is: hydrogen, tar,ACIO, amidoal quilo, hydroxilquilo or alcohy; R3 is prior to hydrogen, alkyl or acyl fluoride; R4 and R5 are independent of each other and are hydrogen or tar, Or an R4 and R5 together with R3 and the atoms between them may form a ring of 3 to 7 rings, which may include a heterogeneous nitrogen or oxygen atom; and each independent R6, R7, R8, R9 and R10 are hydrogen or tar; or an R6 and R7 together with R10 and the atoms connected with them may form a single R10 and R7. Rings 3 to 7, or rings R5 and R7, together with the atoms to which they are attached, can form rings 3 to 7,Or R6 and R7 plus R8 and R9 and the atoms they connect to form a ring of 3 to 7 rings.