Complex Inclusions obtained using a procedure with supercritical CO2 and the complex Agent interaction

摘要

This relates to a preparation method of a soluble inclusion Compound comprising one or more active substances insoluble in an aqueous medium included in one or More Guest molecules.Characterized by understanding the successive Stages: a) contacting one or more active substances with one or More Guest molecules; (b) Implementation of a phase molecular Diffusion by putting you in touch, in a Static manner,A dense Fluid under pressure with the mixture obtained in the Step a) in the presence of one or more agents of dissemination; (c) recovery of soluble inclusion Complex formed in this way. Also refers to the soluble inclusion compound can be obtained through this procedure, in particular a - Cyclodextrin Complex Piroxicam - arginine.