Neurokinin-1 Receptor Antagonists for the treatment of States or conditions that respond to testosterone Elevation, including testosterone deficiency.

摘要

Refers to the use of neurokinin-1 Receptor Antagonists as testosterone replacement therapy. In a further aspect, The Invention relates to the use of neurokinin-1 Receptor Antagonists for the preparation of medicaments for treating States or conditions associated with low testosterone levels, in patients who have low levels of testosterone.In Another aspect The Invention relates to the use of neurokinin-1 Receptor Antagonists for the preparation of medicaments for treating hypogonadism in men.Claim 2: use as claimed in any of claims 1 - 5, wherein the neurokinin-1 antagonist is a compound with the General formula wherein R1 represents 1 - phenyl - 3 - 2 indolilo, indolilo, 3 - or indazolilo benzo [b] thiophene-3 - ILO, opcionalmen You replaced with Halogen or alkyl (c1-3), R2 and R3 independently represent h, halogen,- OCH3, CH3 and CF3, R4, R5 and R6 independently represent h, o, or (c1-4 alkyl, dialkyl (C1 CH2OH, NH2, - 3, - 1) - pyrrolidin-3-yl piperidin yl 1, - I, - (4 - (4 - or - Ilo Ilo, replaced with one or two Methyl groups or metoximetilo, - (4 - (4 - ilamino, ilmetilo, imidazole - 1 - I, ti Omorfolin - 4 - [- 1,1 - ILO, ILO or tiomorfolin - 4 - 3 - oxa - 8 - azabiciclo [3.2.1] oct 8 - ilo; R4 and R5 together can represent a Keto Group, a Group 1,3-dioxan-2-yl ILO, X represents o or s, N has the value 1, 2 or 3 to the Asymmetric carbon Atom 8th, 9th or 10th when n is equal to 1, 2 or 3 respectively.