compound, pharmaceutical composition, method for treating or preventing a disease or disorder associated with pathogenic agonism, inverse agonism or antagonism of the gaba receptor, use of a compound, method for locating gaba receptors in a tissue sample, method for altering gaba a receptor signal transducer activity, method for treating or preventing psychological disorders associated with modulation of the gaba a receptor complex, and process for preparing a compound

摘要

COMPOSITION, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATMENT OR PREVENTION OF A DISEASE OR DISORDER ASSOCIATED WITH PATHOGENIC AGONISM, GABA ~ A ~ RECEPTOR COMPOSITE, GLOBAL RECEIVER COMPONENT, ANTAGON USE METHOD FOR CHANGING GABA ~ A ~ RECEPTOR SIGNAL TRANSDUCTIVE ACTIVITY, METHOD FOR TREATMENT OR PREVENTION OF PSYCHOLOGICAL DISTURES ASSOCIATED WITH GABA ~ A ~ RECEIVER COMPLEX MODULATION, AND, PROCEDURE FOR PREPARING COMPOSITE formula (I): or the pharmaceutically acceptable salts thereof, wherein A, B, C, D, X, R 1, R 2, R 3, R 4, R 5 , and R6 are variables defined herein whose compounds are highly GABA-A ~ brain receptor agonists or inverse agonists or GABA-A ~ brain receptor agonists, antagonists or inverse agonists prodrugs, and are therefore usable in the diagnosis and treatment of ans age, Down syndrome, sleep, seizure and cognitive disorders, depression, benzodiazepine drug overdose, and memory and activity enhancement.