Method for the evaluation and solution of test compounds, method for the diagnosis and prognosis of GPCR related disorders, use of those compounds of test and kit comprising the same

摘要

Method for evaluation and solution of test compounds, method for the diagnosis and prognosis of GPCR related disorders, use of those compounds of test and kit comprising the same.The present invention relates to new methods and compositions for the diagnosis.Treatment and prognosis of disorders related to the receptor protein G coupled (GPCR) through inhibition of regulators of G protein signaling (RGS) proteins.The present invention relates to methods for the selection and evaluation of test compounds useful in intervention and prevention of disorders related to GPCRs,Including neuropsychiatric and cardiovascular disorders.The invention also relates to methods for identifying inhibitors of the expression or activity of RGS which are useful in the modulation of signaling pathways of GPCR.