Use of a nucleic acid, direct correlation between overexpression or functional molecular modification of human sgk homologues and the extent of the q / t interval of an antibody directed against a substrate of a human sgk homologue of a functional activator, or a positive transcriptional regulator, from a human homologue of the sgk family and use of substances selected from the group consisting of glucocorticoids, mineralocorticoids, aldosterone, gonadotropins and cytokines, kit for diagnosing hypertension, kit for diagnosing long qt syndrome and drug

摘要

"USES OF NUCLEIC ACID, DIRECT CORRELATION BETWEEN SUPEREXPRESSION OR FUNCTIONAL MOLECULAR MODIFICATION OF SGK FAMILY HUMANOLOGIES AND THE EXTENSION OF THE Q / T RANGE, ANTIBODY DIRECTED BETWEEN THE NEDD2 CONDENSED TO THE N372 , A FUNCTIONAL ACTIVATOR, OR POSITIVE TRANSCRIPTION REGULATOR, SGK FAMILY HUMAN TYPE, AND SELECTED SUBSTANCES FROM THE GROUP CONSISTING OF GLUCOCORTICIDS, MINERALOCORTICIDES FOR KYNOTOSPHERE, GYNODOTOS, KYNOTOSPHERE QT LONG SYNDROME, AND PHARMACEUTICAL ". The invention relates to the use of single or double stranded nucleic acids containing an hsgk fragment in the diagnosis of hypertonia. Said fragment has a minimum length of 10 nucleotides / base pairs and said fragment further comprises a polymorphism which is the result of the presence or absence of a G nucleotide insert at position 732/733 at intron 2 of the hsgkl gene. The invention also relates to the use of direct correlation between overexpression or functional molecular modification of human sgk homologues and the extent of Q / T time in the diagnosis of long QT syndrome, and the use of the nucleic acid of a human homologue of the sgk gene family or one of its fragments in the diagnosis of long QT syndrome. Single nucleotide polymorphisms (single nucleotide polymorphisms = SNP) in human homologues of the sgk gene family are especially useful in the diagnosis of a congenital predisposition to long QT syndrome. In another aspect, the invention relates to the use of a functional activator or transcriptional factor that enhances expression of the sgk family genes to produce a drug for use in long QT syndrome therapy and / or prophylaxis.