compositions comprising t-cell immunomodulatory or immunosuppressive macrolides in combination with antibacterial agents

摘要

"COMPOSITIONS UNDERSTANDING IMMUNOMODULATING MACROLIDS OR T-CELL IMMUNOSUPRESSORS IN COMBINATION WITH ANTIBACTERIAL AGENTS". The present invention relates to highly compatible or synergistic combinations of a T cell immunomodulatory or immunosuppressive macrolide such as 33-epichloro-33-deoxiascomycin, and an antibacterial agent such as sulfasalazin, ciprofloxacin, ofloxacin, erythromycin or gentamicin optionally with an additional active pharmaceutical agent, especially a retinoid. Such combinations are particularly useful in the treatment of diseases involving suspected or suspected bacterial infection or anticipated bacterial infection, for immunomodulation or immunosuppression in unhealthy conditions where bacterial or suspected bacterial colonization or anticipated bacterial colonization play a role in the skin, such as atopic dermatitis. , contact dermatitis or seborrheic dermatitis, eczema, psoriasis, acne, rosacea, skin peeling, burning, skin itching or inflammatory bowel disease IBD and in situations of bacterial resistance.