compounds, pharmaceutical composition and method of treatment of metabolic bone disease, psoriasis, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer, autoimmune disease, inflammatory bowel disease and augmentation bone strength

摘要

"COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS OF TREATMENT OF BONE, PSORIASIS, LEUKEMIA, COLON CANCER, BREAST CANCER, SKIN CANCER OR PROSTATE, AUTOIN IMMUNE DISEASE CANCER, BREAST CANCER BONE RESISTANCE INCREASE ". Competitive Binding VDR 2-alkylidene-19-nor-vitamin D compounds as well as pharmaceutical compositions for these compounds and methods of synthesizing them are disclosed. These compounds are characterized by high bone calcium mobilization activity and high intestinal calcium transport activity. This results in novel therapeutic agents for the treatment and prophylaxis of diseases where bone formation, particularly osteoporosis, as well as autoimmune diseases such as multiple sclerosis, diabetes mellitus and lupus are desirable. These compounds also exhibit pronounced activity in stopping the proliferation of undifferentiated cells and inducing their differentiation to the monocyte, thus evidencing their use as an anticancer agent and for the treatment of skin conditions such as psoriasis. These compounds also increase both fracture resistance and bone crush strength, proving their use in conjunction with bone replacement surgery, such as hip and knee replacements.