compound comprising a peptide moiety, a spacer moiety and a water soluble polymer moiety and a pharmaceutical composition comprising such a compound

摘要

"COMPOSITE UNDERSTANDING A PART OF PEPTIDE, A SPACER PART AND A PART OF WATER SOLUBLE POLYMER AND A PHARMACEUTICAL COMPOSITION UNDERSTANDING SUCH COMPOSITE". The present invention relates to a compound comprising a peptide moiety, a spacer moiety and a water soluble polymer moiety, such as a poly (ethylene glycol) moiety. The spacer moiety is between the peptide moiety and the water soluble polymer moiety. The spacer portion has the structure: -NH- (CH ~ 2 ~) ~ 244 ~ - ¢ O- (CH ~ 2 ~) ~ 225 ~! ~ ¢ sym! ~ -O ~ ¢ sym! ~ ( CH ~ 2 ~) ~ ¢ sym! ~ -Y- where 244, 225, ¢ sym !, ¢ sym! e ¢ sym! are each integers whose values are independently selected.