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adhesive-like pharmaceutical compositions, orally applicable pharmaceutical compositions and process for the synthesis of norelgestromine e / z-isomers mixtures
adhesive-like pharmaceutical compositions, orally applicable pharmaceutical compositions and process for the synthesis of norelgestromine e / z-isomers mixtures
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机译:胶粘剂样药物组合物,可口服的药物组合物和合成炔诺酮碱e / z异构体混合物的方法
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摘要
"ADHESIVE TYPE PHARMACEUTICAL COMPOSITIONS, ORALLY APPLICABLE PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR THE SYNTHESIS OF NORELGESTROMINE E / Z-ISMER MIXTURES". The invention relates to the pure d- (17α) -13-ethyl-17-hydroxy-18,19-dinorpregn-4-eno-20-yne-3-one-3E-oxime isomer of formula ( IA) to the pure d- (17α-13-ethyl-17-hydroxy-18,19-dinorpregn-4-eno-20-yne-3-one-3Z-oxime isomer of formula (IB) , which are of gestation activity, as well as the process for the synthesis of the mixture of the above isomers and the pure isomers. The invention also relates to pharmaceutical compositions - and the process for their syntheses - which contain both the pure isomer of formula (IA) and the pure isomer of formula (IB) as an active ingredient alone or in combination with other active ingredients ( for example, an estrogen agent) combined with auxiliary pharmaceutical materials generally used in practice.
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