polypeptide variant of factor vii (fvii) or factor viia (fviia), nucleotide sequence, expression vector, host cell, composition, use of a variant, and method for treating a mammal having a disease or disorder in which clot formation is desirable

摘要

"Polypeptide Variant Of Factor VII (FVII) Or Factor VIIA (FVIIA), Nucleotide Sequence, VECTOR EXPRESSION, HOST CELL, COMPOSITION, USE OF A VARIANT VARIANT, OR METHOD FOR A MATERIAL DIFFERIUM MAKE COAGULATION DESIRABLE ". Human Factor VII or Human Factor VIIa Gla domain variants, comprising from 1 to 15 amino acid modifications relative to human Factor VII or human Factor VIIA, wherein a hydrophobic amino acid residue has been introduced by substitution at 34, or having an amino acid substitution at position 36, or having amino acid substitutions at positions 10 and 32 and at least one other amino acid substitution at a position selected from 74, 77 and 116.