Chimeric antu00ecgeno to provoke an immune response, methods to enhance the presentation of antu00ecgeno in a cell that has antu00ecgeno, to activate a cell that has antu00ecgeno,To provoke an immune response, to break the toleru00e1ncia, and to treat a condition immuno treatable, pharmaceutical composition, article of manufacture, and method for producing a chimeric antu00ecgeno,Polinucleotu00ecdeo, microorganism or cell line, and -

摘要

"Antu00ecgeno chimeric to provoke an immune response, methods to enhance the presentation of antu00ecgeno in a cell that has antu00ecgeno, to activate a cell that has antu00ecgeno,To provoke an immune response, to break the toleru00e1ncia, and to treat a condition imunotratu00e1vel, pharmaceutical composition, article of manufacture, and method for producing a chimeric antu00ecgeno,Polinucleotu00ecdeo, microorganism or cell line, and vector ". They are here disclosed compositions and methods to induce immune responses against antigens.In particular, the compounds and methods elicit immune responses against foreign antigens that are otherwise recognized by the host as "self" antigens.Thus breaking host tolerance to those antigens.Introduce the immune system of host with a chimeric antigen comprising an immune response domain binding domain and a target.When the target binding domain comprises an antibody fragment, enhances the immune response against the antigen strange or tolerated.The cells that present antigen absorb, process and present the antigen chimeric, causing both humoral and cellular immune response against the antigen desired.