non-woven nano-fibrous silk fibroin membrane for guided bone tissue regeneration and method of manufacture

摘要

"NON-FIBER NON-FIBER SILK FIBROINE MEMBRANE FOR GUIDED BONE TISSUE REGENERATION, AND MANUFACTURING METHOD OF THE SAME". The present invention relates to a membrane for regeneration of guided bone tissue, and more particularly to a membrane for regeneration of guided bone tissue having a silk fibroin nanofiber structure obtained by the removal of sericin from fiber fibers. Silk are formed as a non-woven fabric, and a method of manufacturing it. A guided bone tissue regeneration membrane according to the present invention has a predetermined strength, biocompatibility, and biodegradability, and can maintain a sustained drug delivery system when drugs are added in the manufacturing process. Additionally, a guided bone tissue regeneration membrane according to the present invention may be modified to suit the condition of use, because a membrane thickness can be adjusted by controlling nanofiber fineness, nanofiber compactness, and size. The pore of a multi-porous structure can be adjusted in a non-woven manufacturing process. A non-fibrous guided bone tissue regeneration membrane according to the present invention is manufactured by rapidly freezing, drying a silk fibroin solution obtained by removing sericin from the silk fibers, and by electroplating. centrifugation after dissolution of the dried silk fibroin in an electro-centrifugation solvent. The membrane according to the present invention has excellent adhesion and air permeability, and is thus effective in regenerating damaged peridontal tissues.