首页> 外国专利> Prophylactic and therapeutic Treatment of Infectious and other diseases with immune effectors compounds

Prophylactic and therapeutic Treatment of Infectious and other diseases with immune effectors compounds

机译:用免疫效应剂化合物预防和治疗感染性疾病和其他疾病

摘要

1. - A method to alleviate or prevent substantially an infectious disease, an autoimmune disease or an allergic condition in a subject, that is to put in contact the subject with an effective amount of one or more compounds of the following formula.Pharmaceutically acceptable salts of the same and, where X is a member selected from the group consisting of - and - NH -, and is a member selected from the group consisting of - or - or - S -, each of R1, R2 and R3 are independently an acyl Group (C2 - C20); R4 is a Member selected from the Group C Composed of H - and po3r7r8,Where each of R7 and R8 are chosen independently of the Group comprising aliphatic groups H and (c1-c4); R5 is a member selected from the group consisting of H, CH3 and po3r9r10, where each Member of R9 and R10 are chosen independently of the Group comprising - H And aliphatic groups (C1 - C4), R6 is selected from h, Oh, oxialifu00e1ticos groups (C1 - C4) - po3r11r12,Opo3r11r12 so3r11 oso3r11 -, -, -, - nr11r12, SR11, - CN, - NO2 - cho2, co2r11 and conr11r12, where each of R11 and R12 are selected independently of aliphatic groups H and (c1-c4), Always and when R4 and R5 is a group containing Phosphorus and - When is po3r7r8 R4, R5 is Different d E - po3r9r10; where "1" * 2 "*" and "*" and "* *" represent Chiral Centers, where n, M, P and Q,Are each independently an integer from 0 to 6, provided that the sum of P and M is 0 to 6.
机译:1-基本减轻或预防受试者的传染病,自身免疫病或过敏性病状的方法,该方法是使受试者与有效量的一种或多种下式化合物接触。其中X是选自-和-NH-的成员,并且是选自-或-或-S-的成员,R 1,R 2和R 3各自独立地是酰基(C2-C20); R4是选自由H-和po3r7r8组成的组C的成员,其中R7和R8中的每一个独立地选自包含脂族基团H和(c1-c4)的组; R5是选自H,CH3和po3r9r10的成员,其中R9和R10的每个成员独立于包含-H和脂族基团(C1-C4)的基团选择,R6选自h,Oh,草醛 u00e1ticos组(C1-C4)-po3r11r12,Opo3r11r12 so3r11 oso3r11-,-,-,-nr11r12,SR11,-CN,-NO2-cho2,co2r11和conr11r12,其中R11和R12均独立于脂族基团H选择和(c1-c4),当R4和R5为含磷基团且-为po3r7r8 R4时,R5始终为d E-po3r9r10;且始终为;其中“ 1 ” * 2 “ * ”以及“ * ”和“ * * ”代表手性中心,其中n,M,P和Q分别为0到6的整数P和M之和为0到6。

著录项

  • 公开/公告号CO5601003A2

    专利类型

  • 公开/公告日2006-01-31

    原文格式PDF

  • 申请/专利权人 CORIXA CORPORATION;

    申请/专利号CO20040084170

  • 发明设计人 JOHNSON DAVID A.;CLUFF CHRISTOPHER W.;

    申请日2004-08-27

  • 分类号A61K31/70;

  • 国家 CO

  • 入库时间 2022-08-21 21:39:53

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号