1-(1,2-Disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivative, its use, process for its preparation, pharmaceutical composition in which it is comprised as well as intermediate for its preparation

摘要

In the present invention, there is disclosed a 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)piperidine derivative of the general formula I, in which n is 0, 1 or 2; m is 1 or 2, provided that if m is 2, then n is 1; =Q represents =O or =Nre3-; X denotes a covalent bond or -O-, -S-, -NRe3-; Re1 represents Are1, Are1alkyl containing 1 to 6 carbon atoms in the alkyl moiety or di(Are1)alkyl with 1 to 6 carbon atoms in the alkyl moiety, wherein each alkyl group is optionally substituted; Re2 represents Are2; Are2alkyl having 1 to 6 carbon atoms in the alkyl moiety, Het or Hetalkyl with 1 to 6 carbon atoms in the alkyl moiety; Re3 represents hydrogen or alkyl containing 1 to 6 carbon atoms; L denotes a piperidine derivative or a spiro piperidine derivative; Are1 represents phenyl or substituted phenyl; Are2 represents naphthalenyl; phenyl or substituted phenyl; and Het denotes a monocyclic or bicyclic heterocycle; wherein each monocyclic and bicyclic heterocycle may optionally be substituted on a carbon atom; N-oxide form thereof, pharmaceutically acceptable addition salt or a stereochemically isomeric form. The above-described derivative that is P substance antagonist can be used as a medicament. Also disclosed are a process and intermediate for its preparation as well as a pharmaceutical composition containing thereof and process for its preparation.