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Process for the preparation of amphiphilic solid support for peptide synthesis, bioorganic and organic chemistry
Process for the preparation of amphiphilic solid support for peptide synthesis, bioorganic and organic chemistry
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机译:用于肽合成,生物有机和有机化学的两亲固体载体的制备方法
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摘要
The present invention fulfils desired specifications generally rarely encountered with existing solid supports such as highly amphiphile behaviour. The solid support described herein is a poly(ethylene or propylene)glycol based polymer that can be useful in solid and liquid phase synthesis, chromatography, scavenging purposes and immobilisation of proteins and reagents. More specifically, the solid support is a cross-linked polyether derived from a cross-linked polyester which is obtained by copolymerization of at least one monomer comprising (a) one-ended polymerizable vinyl or allyl ketone, ester, ether or mixtures thereof with at least one cross-linker having at least two polymerizable terminal end groups, with the exception of epoxy and oxetane end groups, or (b) divinyl benzene. The method for the preparation of the cross-linked polyether is also disclosed.
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