Substituted disiloxanes, process for their preparation and their use for the reversal of multi-drug resistance against drugs (MDR)

摘要

The invention relates to novel substituted disiloxanes, the production thereof and the use thereof as biologically active compounds which greatly inhibit the efflux pump activity of malignant Mdr-tumor cells, the Pgp-resistance of parasitic cells, fungi and bacteria in the ng/ml range, do not act in a toxic manner in vivo even in higher concentrations thereof, are immediately effective after cell substance contact and improve the efficacy of cytostatics to a considerable extent.