TRICYCLIC COMPOUNDS, REPRESENTING PROTECTION KINASE INHIBITORS, TO INCREASE THE EFFECTIVENESS OF ANTI-TUMOR AGENTS AND RADIATIVE THERAPY

摘要

Tricyclic compounds that inhibit protein kinases, such as checkpoint protein kinase 1 (CHK-1), having the formula I (where R, R and R are the same as defined in the description), pharmaceutical compositions containing effective amounts of these compounds or their salts, are useful as a single agent or in combination with an antitumor agent or therapeutic training that has an antitumor effect for the treatment of diseases or conditions such as cancer. The international application was published together with the report on the international one search.