multifunctional u0434u0435u043du0434u0440u0438u043cu0435u0440u044b and u0441u0432u0435u0440u0445u0440u0430u0437u0432u0435u0442u0432u043bu0435u043du043du044bu0435 polymers and their use as delivery systems for drugs and genetic material

摘要

the present invention relates to the synthesis of multifunctional u0434u0435u043du0434u0440u0438u043cu0435u0440u043du044bu0445 and u0441u0432u0435u0440u0445u0440u0430u0437u0432u0435u0442u0432u043bu0435u043du043du044bu0445 polymers that can be used as u0434u043eu0441u0442u0430u0432u043a systems and drugsbiologically active pharmaceutical compounds and as gene delivery systems (carriers of genetic material) obtained by condensation with the genetic material.in particular, the present invention relates to the synthesis of multifunctional compounds on the basis of suitable u0434u0435u043du0434u0440u0438u043cu0435u0440u043du044bu0445 and u0441u0432u0435u0440u0445u0440u0430u0437u0432u0435u0442u0432u043bu0435u043du043du044bu0445 polymerson the u0442u0435u0440u043cu0438u043du0430u043bu044cu043du0443u044e surface which are functional groups x, y and z.in addition, for the delivery of genes into cells of these multifunctional systems u043au0430u0442u0438u043eu043du0438u0437u0438u0440u0443u044eu0442 to form complexes with negatively charged genetic u043cu0430u0442u0435u0440u0438u0430 the crowbar.the functional groups provide recognition of delivery systems u043au043eu043cu043fu043bu0435u043cu0435u043du0442u0430u0440u043du044bu043cu0438 receptor cells.moreover, they provide the stability of these systems in the biological environment and facilitate their transport through the cell membrane.