DERIVATIVES OF 1,2,4-SUBSTITUTED 1,2,3,4-TETRAHYDRO- and 1,2-DIHYDROCHINOLINES AND 1,2,3,4-TETRAHYDROCHINOXALINE AS AN INHIBITORS CETR FOR THE TREATMENT OF ATHEROSCLEROSIS AND FAT

摘要

The quinoline and quinoxaline compounds of formulas I and III, where the substituents have the meanings indicated in claims 1 and 15, pharmaceutical compositions containing these compounds, and the use of these compounds to increase the levels of certain plasma lipids, including high-density lipoprotein-cholesterol, and for lowering levels of some other plasma lipids, such as LDL-cholesterol and triglycerides, and accordingly for treating diseases that are exacerbated by low levels of HDL-cholesterol and / or high levels of LDL-choles sterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.