Derivatives of substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido 1,2-a pyrimidine-4-one and 7-pyrimidinyl-2,3-dihydroimidazo 1,2-a pyrimidine-5 (1H) It is for neurodegenerative disorders

摘要

This invention relates to a pyrimidone derivative represented by formula (I), or a salt thereof, where X is two hydrogen atoms, a sulfur atom, an oxygen atom or a C1-6 alkyl group and a hydrogen atom; Y represents a bond, ethenylene group, ethynylene group, oxygen atom, sulfur atom, sulfonyl group, sulfoxide group, carbonyl group, possibly substituted nitrogen atom; or a possibly substituted methylene group; R1 is a possibly substituted pyrimidine group; R2 may be a C1-6 alkyl group optionally substituted by Saryloxy or Sarylamino; Stsikloalkilnuyu group Salkiltiogruppu, Salkoksigruppu, Spergalogenirovannuyu alkyl group Cgalogenirovannuyu alkyl group, a phenylthio group, a benzyl group, a benzene ring, an indane ring, a 5,6,7,8-tetrahydronaphthalene ring, a naphthalene ring, a pyridine ring, a pyrrole ring, a thiophene ring, a furan ring or imidazole ring; R3 and R4 each independently represents a hydrogen atom, a C1-6 alkyl group, a hydroxy group, a Salkoxy group or a halogen atom; R5 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom. This invention also relates to a drug containing said derivative or a salt thereof as an active ingredient, which is used for prophylactic and / or therapeutic treatment of a neurodegenerative disease caused by the abnormal activity of GSK3β3 or GSK3β3 and cdk5 / p25, such as Alzheimer's disease.