Heteroarilos merged with pyrazines and pyridines, pyrimidines, Pharmaceutical composition containing them and Methods for demonstrating the presence of CRF receptors in biological samples, useful in the treatment of Anxiety and eating disturbances or

摘要

Heteroaryl compounds fused with pyridines, pyrazines and pyrimidines of formulas Ia, Ib, XX, Ia Ib XX where Z1, Z2, Z3, Z4, Z5, E, Ar and R are useful in the treatment of divers peripheral disorders of the central nervous system, particularly stress, anxiety, depression,Cardiovascular disease and eating disorders; pharmaceutical ingredients that contain these diseases; and methods of detecting the location of chronic respiratory diseases in biological samples.