CRYSTALLINE FORM III R-(R*R*) - 2 - (4 - FLUOROPHENYL)-??- ??- DIHYDROXY - 5 - (1-METHYL-ETHYL) 3 - PHENYL- 4 - (PHENYLAMINO) CARBONYL - 1H - PYRROLE - 1 HEPTANOIC ACID HEMI CALCIUM SALT HYDRATE (ATORVASTATIN)

摘要

A novel crystalline form of [(R-(R*,R*)]-2-(4-fluorophenyl)- beta , delta -dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt designated Form III is characterized by its X-ray powder diffraction and/or solid state NMR is described, as well as methods for the preparation and pharmaceutical composition of the same, which is useful as an agent for treating hyperlipidemia and hypercholesterolemia.