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USE OF DONOR ANTIGENS FROM A NON-SYNGENEIC DONOR IN THE MANUFACTURE OF A MEDICAMENT FOR INDUCING STABLE AND DONOR -SPECIFIC TOLERANCE TO NON-SYNGENEIC TRANSPLANT IN A HOST
USE OF DONOR ANTIGENS FROM A NON-SYNGENEIC DONOR IN THE MANUFACTURE OF A MEDICAMENT FOR INDUCING STABLE AND DONOR -SPECIFIC TOLERANCE TO NON-SYNGENEIC TRANSPLANT IN A HOST
The present invention features a method of inducing donor-specific tolerance in a host. Tolerogenic treatments of the present invention may be administered to a host prior to transplantation of donor-derived materials. The tolerogenic treatment involves (1) administering an immunosuppressive agent to a host mammal in a non-myeloablative regimen sufficient to decrease, but not necessarily to eliminate, the host mammal's functional T lymphocyte population; (2) infusing donor antigens from a non-syngeneic donor into the host mammal; (3) eliminating those host T lymphocytes responding to the infused donor antigens using a non-myeloablative dose of lymphocytotoxic or tolerizing agent; and (4) administering donor hematopoietic cells to the host mammal.
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