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A RECOMBINANT PROTEIN COMPLEX, METHODS FOR ITS PREPARATION AND IN VITRO METHODS FOR IDENTIFYING COMPOUNDS RELATED TO INFLAMMATION AND APOPTOSIS
A RECOMBINANT PROTEIN COMPLEX, METHODS FOR ITS PREPARATION AND IN VITRO METHODS FOR IDENTIFYING COMPOUNDS RELATED TO INFLAMMATION AND APOPTOSIS
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机译:重组蛋白复合物,其制备方法和鉴定与炎症和凋亡相关的化合物的体外方法
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摘要
The present invention relates to, among other embodiments, protein complexes which include tumor necrosis factor alpha (TNF-α) and/or tumor necrosis factor alpha receptor (TNFR). Preferably, the complexes comprise at least one polypeptide selected from the group consisting of: NF-ĸB activating kinase (NAK), RasGAP3, TRCP1, and TRCP2. The present invention further provides assays of identifying a compound for modulating the stability and activity of the complex. Also provided are methods of modulating apoptosis and inflammation, as well as treating TNF-α related diseases.
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