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USE OF HIGHLY SELECTIVE NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE PREPARATION OF MEDICAMENTS FOR THE TREATMENT OF MENTAL AND NEUROLOGICAL DISORDERS
USE OF HIGHLY SELECTIVE NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE PREPARATION OF MEDICAMENTS FOR THE TREATMENT OF MENTAL AND NEUROLOGICAL DISORDERS
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机译:高度选择性的去甲肾上腺素再摄取抑制剂在制备用于治疗精神和神经疾病的药物中的用途
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摘要
Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a compound having a pharmacological selectivity of serotonin (Ki)/norepinephrine (Ki) of at least about 5000. Examples of such compounds include reboxetine, and more preferably optically pure (S,S) enantiomer of reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.
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