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T CELL EPITOPES USEFUL IN A SEVERE ACUTE RESPIRATORY SYNDROME (SARS) VIRUS VACCINE AND AS DIAGNOSTIC TOOLS AND METHODS FOR IDENTIFYING SAME
T CELL EPITOPES USEFUL IN A SEVERE ACUTE RESPIRATORY SYNDROME (SARS) VIRUS VACCINE AND AS DIAGNOSTIC TOOLS AND METHODS FOR IDENTIFYING SAME
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机译:严重急性呼吸道综合症(SARS)病毒疫苗中常用的T细胞表位,并作为诊断工具和方法进行鉴别
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摘要
In a first aspect the present invention consists of T cell epitopes in the Severe Acute Respiratory Syndrome (SARS) virus genome. More specifically there is provided 180 class I linear peptide epitopes and 200 class II linear epitopes from the SARS Virus genome. In a second aspect the invention also consists of variants of these sequences. In a third aspect this invention consists of a method to predict these sequences from genome data and to validate the predications experimentally. In a fourth aspect the present invention provides compositions including these epitopes for use in a vaccine and to induce a T cell response in a subject, or as a diagnostic tool.
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