NOVEL ANTI-INSULIN/IGF-I HYBRID RECEPTOR OR ANTI-INSULIN/IGF-I HYBRID RECEPTOR AND IGF-IR ANTIBODIES AND USES THEREOF

摘要

The present invention relates to novel antibodies capable of binding specifically to i) the human anti-insulin/IGF-I hybrid receptor (hybrid-R) or ii) both to said hybrid-R and the human insulin-like growth factor I receptor (IGF-IR) and/or capable of specifically inhibiting the tyrosine kinase activity of said hybrid-R or both hybrid-R and IGF-IR, especially monoclonal antibodies of murine, chimeric and humanized origin, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing, or with an abnormal activation of, hybrid-R or of both hybrid-R and IGF-IR or any pathology connected with the overexpression, or abnormal activation, of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the hybrid-R or both hybrid-R and IGF-IR. The invention finally comprises products and/or compositions comprising such antibodies in combination with anti-EGFR antibodies and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.