HARD CAPSULE SHELL CONSISTING OF GELATIN AND HYDROXYPROPYL METHYLCELLULOSE AND NOVEL METHOD OF PREPARATION THEREOF

摘要

A novel hard capsule shell consisting of gelatin and hydroxypropyl methylcellulose (HPMC) and method of preparation thereof in which, preparing a mixture of 100 liters consisting of purified water and ethyl alcohol (8:2). After mixing thoroughly the mixture is dispersed with 3 Kg. HPMC and 10 Kg. Gelating. Heating to 60ºC with intermittent stirring till homogeneity is obtained, colling the dispersion to 45ºC. preparing Cap/Body of the capsule shell by repeatedly dipping stainless steel rods in dispersion. Inverting these roads till drying and deta and detached from the rods. A novel capsule shell consist of gelatin and a film former HPMC or combination of more than one film former. In addition also contain one or more plasticizer. Hydroalcholic solution is used as solvent in various ration of 5:5, 6:4 and 8:2. This novel capsule shell is proposed to nullify the slowing down of dissolution of shell on aging. Drawing Sheets: NIL Total Pages: 18. Fig. Nil