EXTRACT OF PERICARP OF THE FRUIT SAPINDUS TRIFOLIATUS COMPRISING SAPONIN

摘要

HERBAL EXTRACT COMPRISING A MIXTURE OF SAPONINS OBTAINED FROM SAPINDUS TRIFOLIATUS FOR ANTICONVULSANT ACTIVITY An extractr of the pericarp of the fruit of Sapindus trifoliatus comprising a mixture of triterpenoid saponins comprising from 0.001 to 1.0 (%w/v) of hederagenin. A pharmaceutical composition comprising the said extract and having binding affinities for the receptor sites viz GABA-A agonist site, Glutamate-AMPA site, Glutamate-Kainate site, Glutamate-NMDA agonistic site, Glitamate-NMDA glycine (strychnine insensitive) site and sodium channel (site 2) having major mediatory role in anticonvulasant activity The composition capable of prophlactic treament of migraine mediated through anticonvulant aqctivity.