1,2,3,4-tetrahydroquinoline and 1,2,3,4-tetrahydroquinoline 1,2,4-substituted derivatives as CETP inhibitors for the treatment of atherosclerosis and obesity

摘要

1,2,3,4-tetrahydroquinoline and 1,2-dihydroquinoline and 1,2,3,4-tetrahydroquinoline derivatives 1,2, 4-substituents of CETP inhibitors for the treatment of atherosclerosis and obesity, pharmaceutical compositions containing the compounds, and the use of the compounds in the treatment of atherosclerosis and obesity Increase plasma levels of some lipids including HDLAnd reduce plasma levels of some other lipids, such as cholesterol LDL and triglycerides, to treat diseases exacerbated by low cholesterol HDL and / or high cholesterol LDL and triglycerides, For example, some mammals, including human atherosclerosis and cardiovascular disease.