Compounds such as fused ring pyrazolones which inhibit the release of inflammatory cytokines, thereby controlling and preventing ezymes responsible for various diseases

摘要

Compounds of formula (I) including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof which are capable of preventing the extracellular release of inflammatory cytokines are disclosed, wherein: R, R1, R2a and R2b are as defined in the specification (preferably R comprises ethers or amines; R1 is: (a) substituted or unsubstituted aryl or (b) substituted or unsubstituted heteroaryl; R2a and R2b units are each independently hydrogen, ethers, amines, amides, carboxylates, or said units can form a double bond, a carbonyl, or R2a and R2b can be taken together to form a substituted or unsubstituted ring comprising from 4 to 8 atoms, said ring selected from the group consisting of: (i) carbocyclic; (ii) heterocyclic; (iii) aryl; (iv) heteroaryl (v) bicyclic and (vi) heterobicyclic).