Method for Preparation of a Bivalent Vaccine against Addiction to morphine and heroin

摘要

Refers to a preparation method of an intermediary - 6 - hemisuccinate Derivative of morphine, which comprises: a) reacting SUCCINIC anhydride 2 g per gram of morphine base; (b) incubating at 70 - 80 oC with 20 ml of benzene, pyridine or Dry during 6 hours; (c) to cool to room temperature.Decant the excess of Pyridine and benzene; (d) the rest of these organic compounds evaporate and washed 10 times with 60% ethanol in distilled Water to recrystallize The residue.The Invention also refers to a process of preparing a vaccine comprising: (1) through the condensation REACT covalently with a secondary intermediary intermediary reactive molecular complex of Tetanus toxoid - TFCs; 2) Incubating the Reaction mixture for 2 - 3 hours at temperature Environment and slow agitation or constant; 3) PurifySterilize sterile bottles and lyophilize Vaccine. The vaccine is capable of inducing a humoral immune response against addictive Opiate Drugs through Active Immunization in humans