Condensed pyrazole derivatives as agonists of the cannabinoid receptors CB1 or CB2 and /

摘要

Pyrazole Derivative of a compound of formula I, where a is alquileno c3-c5, - CH2 - or - CH2 CH2, among others; W is a direct link or CH2; r1 is H, or C1 - C3 alkyl; R2 is alkyl C1 - C10, B - R4 R3 is phenyl, among others; substituted c1-c4 alkyl, halogen, among others; b is a direct link. Alquileno C1 - C2Among others; R4 is not substituted phenyl or substituted by one or more substituents selected from Halogen, c1-c4 alkyl, among others. Preferred compounds are: adamantil - N - 1 - 1 - (3,4-dichlorophenyl) 1,4,5,6 - tetrahidrociclopenta [c] pyrazole-3-carboxamide, N - [(1S) - 1 - ciclohexiletil] - 1 - (3,4-dichlorophenyl) 1,4,5,6 tetrahidrociclopenta 6,6 Dimethyl pyrazole - [c] - 3 - carboxamide, among others.It also relates to a Pharmaceutical Composition and a preparation method. These compounds are agonists of the cannabinoid receptors CB1 and CB2 and / or are useful for the treatment of migrana, stress, Psychosomatic disease, Spinal Cord Injuries, among others