Compounds of 3H - and 3h tiazolo oxazolo 4,5-d pyrimidine 2 - 3.5 - and disustituida ONA - trisustituida 3,5,7 and prodrugs of the same

摘要

Referring to a pirimidinona derivative Compound of formula (i), where X is o or s, and S; r1 is H, cycloalkyl, aryl, among others; R2 is NHC (NH2, - or - NHR5 R4), among others; R4 is C1 - C7 or alkyl (alkyl - or C1 - C7); R5 C1 - C7 is alkyl; R3 is H, CL, BR, among others.Preferred compounds are: 2 - amino - 4 - (2 '- methyl - B - C - D - ribofuranosil) - 3H tiazolo [4,5-d] pyrimidine 2 - ona, amino - 5 - 3 - (2' - Deoxy - B - D - [3H tiazolo ribofuranosil) - 4.5 - 2 - d] pyrimidine Ona, amino - 5 - 3 - (2 '- O - acetyl - 3' - Deoxy - B - D - ribofuranosil) - 3H tiazolo [4,5-d] pyrimidine 2 - ona, among others. Also referred to a Pharmaceutical composition.These compounds are useful in the treatment of infections caused by adenovirus, cytomegalovirus, hepatitis C virus, among others