Polymorphous variety of 2-(R)-{1-(R) -3,5-bis(trifluoromethyl) -phenylethoxy}-3-(S)-(4-fluoro)phenyl-4-3-(5-oxo-1H,4H-1,2,4-triazole)methyl morpholine an antagonist of tachykinin

摘要

This invention is concerned with a novel polymorphic form of the compound 2-(R)-(1-(R) -(3,5-bis(trifluoromethyl) -phenyl)-ethoxy)-3-(S)-(4-fluoro) phenyl-4-(3-5 (-oxo-1H,4H-1,2,4-triazolo) methylmorpholine which is a tachykinin receptor antagonist useful in the treatment or prevention of disorders of the central nervous system, inflammatory diseases, pain or migraine, asthma, and emesis. The instant polymorphic form has advantages over the other known forms of 2-(R)-(1-(R) -(3,5-bis(trifluoromethyl) -phenyl)ethoxy)-3-(S )-(4-fluoro) phenyl-4-(3-5 (-oxo-1H,4H-1,2,4-triazolo) methylmorpholine in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations.